Healthcare & Life Sciences · Agent 03 · on IBM watsonx Orchestrate

Design the trial. Carry the dossier.

In plain English: Quantum Rx runs the clinical & regulatory pipeline end to end — trial design, patient stratification, companion diagnostics, pharmacoeconomics, FDA IND assembly — thirteen tools, five genuinely quantum. Every record sealed to 21 CFR Part 11 / HIPAA standards.

13
tools · trial design → IND
5
quantum · QAE · QSVM · QAOA
14
IBM Heron jobs · resolvable
v3.0.0
engine · epoch-agent
The problem we exist to solve

The science is hard. The paperwork is fatal.

01 · Underpowered

A trial too small to prove anything

Size it wrong and you spend years to reach an inconclusive readout. The sample size is a decision you can't take back.

02 · Unstratified

The right drug, the wrong patients

Without companion diagnostics and stratification, a drug that works for a subgroup fails the whole population — and the program dies.

03 · Unassembled

An IND that won't pass review

FDA IND assembly and 21 CFR Part 11 records are unforgiving. A dossier with a gap is a clinical hold you didn't budget for.

01 · The pipeline

Stratify, size, submit.

Thirteen tools spanning T0–T3 — five run genuine quantum (QAE, QSVM, QAOA), exact statevector below the router threshold and real IBM Heron above it, with resolvable job IDs.

Trial design

Power and sample-size optimization, adaptive designs and synthetic control cohorts — sized to prove what you need to prove.

QAOAclosed-form power

Stratification

Companion-diagnostics matching and patient stratification — the right drug to the right responders.

QSVMcompanion_diagnostics

Economics & safety

Pharmacoeconomic / QALY analysis and pharmacovigilance — value and adverse-event signal, on the same record.

QAEpharmacoeconomic_qaly

Regulatory

Regulatory-pathway mapping and automated FDA IND dossier assembly — sealed to 21 CFR Part 11.

ind_package_generator · regulatory_qaoa
02 · The trial designer

Size the study. Seal the design.

A working trial-design tool. Enter your endpoint and the designer computes the sample size to power it — adjusted for dropout — places the study on the development pipeline, runs the IND-readiness checklist, and seals the design. The deterministic power calculation the QAOA path optimizes against.

clinical_trial_optimizer · two-arm endpoint

Two-arm · superiorityPhase II ready
160 per arm
377 enrolled · 320 evaluable after 15% dropout
+15 pts
Absolute effect
1.96 / 0.84
z(α/2) / z(β)
377
Total enrollment
In-browser demonstration. The closed-form power calculation, sealed locally with real WebCrypto SHA-256. The production agent runs the full pipeline + QAOA design optimization on watsonx Orchestrate.
03 · How a design is sealed

Stratify. Size. Seal.

01 · STRATIFY
The right cohort

QSVM companion-diagnostics matching defines the population where the drug actually works.

02 · SIZE
Powered to prove it

Closed-form power sets the sample size; QAOA optimizes the adaptive design — exact statevector or real IBM Heron.

03 · SEAL
21 CFR 11 record

Design, inputs and assumptions sealed Ed25519 + ML-DSA to a WORM ledger — IND-ready, 7-year retention.

Honest, and verifiable in minutes. Five tools (QAE, QSVM, QAOA) execute live — exact statevector (the noiseless ideal, calibrated-equivalent to a QPU below the router threshold) or a real IBM Heron QPU above it. Batched Heron job d8t0s1cbp3hs7383qq4g (ibm_kingston, simulator:false, DONE) plus 13 further real jobs are catalogued. Closed-form outputs are recomputable by hand; every required-field tool rejects empty input with no invented result.
04 · The thirteen tools

Trial to IND. One agent.

Tool
What it does
clinical_trial_optimizer
Power, sample size & adaptive design (QAOA).
companion_diagnostics_qsvm
Match companion diagnostics to responders.
pharmacoeconomic_qaly
Cost-effectiveness / QALY analysis (QAE).
ind_package_generator
Auto-assemble the FDA IND dossier.
synthetic_patient_data · real_world_evidence_miner
Synthetic cohorts & real-world evidence.
adverse_event_detector · pharma_compliance_engine
Pharmacovigilance + 21 CFR 11 / HIPAA sealing.
Sealed · Ed25519 + ML-DSA-65 FDA IND21 CFR Part 11HIPAASEC 17a-4FINRA 4511

Take the program to the clinic.

Add Quantum Rx to your watsonx Orchestrate workspace, or let the Prompt Builder wire it into a stratify-size-submit chain.

EpochCore, LLC · research tooling, not medical advice · quantdev@epochcoreqcs.com